Your Heartburn Medicine Might Give You a Heart Attack

The symptoms of heartburn can make you feel like your heart is on fire, but taking medication to soothe it may put you at a higher risk for a heart attack. Research from Stanford University has linked common heartburn medications with a higher potential to suffer heart attacks.

Scientists from Stanford University collected the electronic medical records of over three million patients, whose personal information had been removed. They reviewed the records for any associations between people with incidents of heart attacks and heartburn medication use.

Specifically, they were looking for the use of proton-pump inhibitors (PPIs), such as Prevacid, Nexium, and Prilosec. These PPIs are so commonly used that their sales revenue adds up to roughly 14 billion dollars each year. It is estimated that approximately 20 million Americans regularly take medications to treat heartburn symptoms.

When some laboratory experiments indicated a possible link between heart tissue and PPIs, it led researchers to wonder about the association. This is what prompted study author Nigam Shah, an assistant professor of medicine and biomedical informatics at Stanford, along with team members from a private company, to begin searching medical records for links between the patients who took PPIs and heart attacks.

Findings did indicate a correlation with a modest increase in risk

“The increase in risk is about 16 to 20 percent, depending on the particular drug involved,” said Shah.

“The AHA (American Heart Association) estimates a heart attack happens every 34 seconds in America. If we’re estimating this risk is increasing by 20 percent [with PPI use], the public health impact is substantial,” said senior study author Nick Leeper, an assistant vascular surgery and cardiovascular medicine professor at Stanford University.

“The problem is, it’s very easy to do studies of this sort that lead to conclusions that can be misleading. I know because I’ve done that myself,” says Dr. David Juurlink, a drug-safety researcher at the University of Toronto, who was not involved in the study.

While the findings do seem to indicate a modest link between taking PPIs and an increased risk for heart attack, the risk is still very minimal. When taking the population as a whole, the risk is quite small, particularly to those who are at a lower risk for heart attacks to begin with.

“If your risk of a cardiovascular event or a heart attack is one in a million, now it is 1.2 in a million,” clarified Shah.

This could be problematic for people who are already vulnerable

It becomes more worrisome when taken into consideration for people who have a higher risk of suffering a heart attack in their lifetime. Even a small increase in risk for someone who is already vulnerable can make a real difference.

“I wouldn’t want the public to panic and to say we should stop taking these drugs,” said Shah. However, he wants people to be aware of the risk, particularly those at the higher than average risk for heart attack. “And if your baseline risk is high, then maybe you want to take something else.”

There are other risk factors for heart attack that are likely a far greater concern. As Juurlink pointed out, “Having a bad diet, drinking too much alcohol, smoking, all sorts of other things… might lead people to be on a PPI,” but obviously those risky lifestyle choices will already put them at a higher risk for suffering a heart attack.

“Drugs are brought to market because of randomized trials, typically with a few thousand patients. And then they get used in patients who are very, very different from the patients in randomized trials,” says Juurlink. “They get used in sicker patients; they get used for longer durations of time and at different doses. So it’s really important that studies like this get done.”

“We don’t recommend anyone change their practice — what we’re really recommending at this time is a prospective study,” said Leeper.

Considering that most medications run risks for side effects of one kind or another, isn’t it a great time to look at some alternative methods to treat heartburn?

Recommended Articles

Delaying Retirement Can Potentially Delay Dementia

They say that retirement should be viewed as a new life adventure. But it is really a budgeting lifestyle for post-working life. And there are a lot of considerations to

Attention Ladies: These Herbs Are Important to Your Health

Women have so many demands on their bodies and minds that any relief is a blessing. That is why you need to start taking these herbs to help increase your

4 Rules That Will Bombproof Your Retirement

Financial markets often are directly correlated to the macroeconomic, social and political factors far out of our control. Herds of investors are prone to reacting in extremes whenever these macro

4 Types of Retirement Income That Will Be Taxed

As well all know, expenses may change from one year to the next, and the amount you spend may change throughout retirement as well. That's why, for many current and

Study Finds Risks of Two Commonly Taken Antidepressants

Depression is a serious mental illness — one that affects more than 15 million adults in the U.S. For some women, pregnancy can bring about new depression symptoms, or worsen

Live Near Water? You Probably Paid Too Much for Your House. Here’s Why (Map)

Even a cynic recognizes that opportunity is a key to prudent business timing. Consider home buying. If you’re in the market for a new home, and are informed and discerning

3 Reasons to Should Avoid Life Settlement Policies

Most Americans don’t take life insurance for granted because almost one out of every two Americans don’t have it. According to the Insurance Information Institute, only about 54% of Americans

Feeling Hangry? How to Avoid Food-Related Mood Swings

Food that you eat is processed into simple sugars, free fatty acids and amino acids. The nutrients are moved into the bloodstream where they are assimilated by organs, tissues, and

How to Put Your Investments On Autopilot — and Win

Are you committed to investing a part of your monthly income towards retirement? You can insulate your financial future against unforeseen emergencies and economic risks if you use an automatic

Best Time to Sell or Buy a Home? It Depends…

When's the best time to buy or sell a home? That's a great question. A lot depends on who you are, seller or buyer. Traditionally, the best time of year

6 Sneaky Habits That May Be Causing Your Overeating

Overeating? Many people vastly underestimate how many calories they consume in a day. Even if you believe you restrict your daily calorie consumption, you may be consuming more calories than

How Shark Tank Judge Barbara Corcoran Nearly Lost $400,000 — Just by Reading an Email

According to a 2017 FBI Internet Crime Report, individuals and companies lost over $5.5 billion between 2013 through 2017 due to email phishing scams. Email phishing scams are deceptive emails